Txij li thaum pib muaj kev sib kis, kev kuaj mob tau ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev sib kis ntawm SARS-CoV-2, tus kab mob uas ua rau.COVID 19.Kev ntsuam xyuas sai antigenua hauv tsev lossis hauv chaw kho mob muab cov txiaj ntsig hauv 15 feeb lossis tsawg dua.Tus neeg raug kuaj pom ua ntej, lawv tuaj yeem nrhiav kev kho mob sai thiab cais lawv tus kheej ntawm lwm tus.Tab sis thaum cov kab mob tshiab tshwm sim, cov kev hloov pauv no yuav tsis raug kuaj pom los ntawm cov kev sim no.
Feem ntau cov tshuaj tiv thaiv kab mob sai sai yog tsim los kuaj pom SARS-CoV-2 nucleocapsid protein lossis N-protein.Cov protein no muaj nyob rau hauv ntau hauv cov kab mob thiab cov neeg muaj kab mob.Cov khoom siv ceev ceevs feem ntau muaj ob hom tshuaj tiv thaiv kab mob sib txawv uas khi rau qhov sib txawv ntawm N protein.Thaum cov tshuaj tiv thaiv kab mob khi rau N protein hauv ib qho qauv, kab xim lossis lwm yam teeb liab tshwm rau ntawm cov khoom siv kuaj, qhia tias muaj kab mob.
Protein N muaj 419 amino acid structural units.Ib qho ntawm lawv tuaj yeem hloov tau los ntawm lwm cov amino acid los ntawm kev hloov pauv.Pab pawg tshawb fawb coj los ntawm Ph.D.Philip Frank thiab Eric Ortlund ntawm Emory University tau teeb tsa los tshawb xyuas seb qhov kev hloov pauv amino acid no cuam tshuam li cas rau kev ua tau zoo ntawm kev sim tshuaj tiv thaiv sai.Lawv tau siv cov txheej txheem hu ua kev hloov pauv sib sib zog nqus mus rau tib lub sijhawm ntsuas seb txhua qhov kev hloov pauv hauv N protein ntawm tus kab mob cuam tshuam li cas rau kev khi rau cov tshuaj tiv thaiv kab mob.Lawv cov txiaj ntsig tau tshaj tawm hauv Cell thaum lub Cuaj Hlis 15, 2022.
Cov kws tshawb fawb tau tsim lub tsev qiv ntawv dav dav ntawm ze li 8,000 N protein hloov pauv.Cov variants no suav nrog ntau dua 99.5% ntawm tag nrho cov kev hloov pauv tau.Tom qab ntawd lawv tau soj ntsuam seb txhua qhov sib txawv cuam tshuam li cas nrog 17 qhov sib txawv ntawm cov tshuaj tiv thaiv kab mob siv hauv 11 kev lag luam muaj cov tshuaj tiv thaiv sai sai, suav nrog ntau yam.cov khoom siv hauv tsev.
Pab pawg tau soj ntsuam seb qhov kev hloov pauv N-protein cuam tshuam rau kev paub txog cov tshuaj tiv thaiv kab mob.Raws li cov ntaub ntawv no, lawv tau tsim ib qho "kev hloov pauv hloov pauv" rau txhua qhov tshuaj tiv thaiv kab mob.Qhov profile no qhia txog kev hloov pauv tshwj xeeb hauv N protein uas yuav cuam tshuam rau lub peev xwm ntawm cov tshuaj tiv thaiv kab mob los khi rau nws lub hom phiaj.Qhov kev tshuaj ntsuam tau pom tias cov tshuaj tiv thaiv uas siv rau hauv cov kev sim sai niaj hnub no paub thiab khi tag nrho cov kev hloov pauv yav dhau los thiab tam sim no ntawm SARS-CoV-2 ntawm kev txhawj xeeb thiab kev txhawj xeeb.
Txawm hais tias ob peb cov tshuaj tiv thaiv kab mob paub txog tib cheeb tsam ntawm N protein, cov kws tshawb fawb pom tias txhua cov tshuaj tiv thaiv kab mob muaj qhov tshwj xeeb kos npe ntawm kev hloov pauv.Raws li tus kab mob SARS-CoV-2 txuas ntxiv hloov pauv thiab tsim cov kev hloov pauv tshiab, cov ntaub ntawv no tuaj yeem siv los chij cov khoom siv tshuaj tiv thaiv kab mob uas yuav tsum tau rov ntsuas dua.
"Kev txheeb xyuas kom raug thiab ua tau zoo ntawm cov neeg muaj tus kab mob tseem yog lub tswv yim tseem ceeb rau kev txo qis COVID-19, thiab peb txoj kev tshawb fawb muab cov ntaub ntawv qhia txog kev hloov pauv ntawm SARS-CoV-2 yav tom ntej uas tuaj yeem cuam tshuam nrog kev tshawb pom," Ortlund tau hais."Cov txiaj ntsig tau teev tseg ntawm no tso cai rau peb hloov kho sai sai rau tus kab mob no vim tias muaj kev hloov pauv tshiab txuas ntxiv, nthuav tawm qhov cuam tshuam rau kev kho mob thiab pej xeem kev noj qab haus huv tam sim ntawd."
Keeb kwm: Mutation Deep Scan pom kev khiav tawm ntawm kev hloov pauv hauv SARS-CoV-2 nucleocapsid siv tam sim no muaj cov tshuaj antigen sai.Frank F., Kin MM, Rao A., Bassit L., Liu H, Bowers HB, Patel AB, Kato ML, Sullivan JA, Greenleaf M., Piantadosi A., Lam VA, Hudson VH, Ortlund EA cell.2022 Cuaj hlis 15; 185(19): 3603-3616.e13.Ministry of Interior: 10.1016/j.cell.2022.08.010.Aug 29, 2022 PMID: 36084631.
Cov Nyiaj Txiag: Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv Hauv Tebchaws rau Biomedical Imaging thiab Bioengineering NIH (NIBIB), National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) thiab National Institute of Allergy and Infectious Diseases (NIAID), American Heart Association.
NIH Kev Tshawb Fawb Cov Teeb Meem yog qhov hloov tshiab txhua lub lim tiam ntawm NIH cov kev tshawb fawb tseem ceeb tau tshuaj xyuas los ntawm NIH cov kws tshaj lij.Nws yog luam tawm los ntawm Kev Sib Txuas Lus thiab Kev Ua Haujlwm Hauv Pej Xeem ntawm Tus Thawj Coj ntawm National Institutes of Health.